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Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability
Voskobiynyk, Y., J.R. Roth, J.N. Cochran, T. Rush, N.V.N. Carullo, J.S. Mesina, M. Waqas, R.M. Vollmer, J.J. Day, L.L. McMahon, and E.D. Roberson. (2020). Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability. eLife 10.7554/eLife.57354.
Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations
Arrant, A.E., J.R. Roth, N.R. Boyle, S.N. Kashyap, M.Q. Hoffmann, C.F. Murchison, E.M. Ramos, A.L. Nana, S. Spina, L.T. Grinberg, B.L. Miller, W.W. Seeley, and E.D. Roberson. (2019). Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. Acta Neuropathol. Commun. 7:218
A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity
Rush, T., J.R. Roth, S.J. Thompson, Adam R. Aldaher, J.N. Cochran, and E.D. Roberson. (2019). A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity. Neurobiol. Dis. doi: 10.1016/j.nbd.2019.104668.
Neurodegenerative Disease–Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain
Dean, H.B., E.D. Roberson, and Y. Song. (2019). Neurodegenerative Disease–Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain. Front. Neurol. DOI: 10.3389/fneur.2019.01252.
Progranulin gene therapy improves lysosomal function and microglial pathology associated with frontotemporal dementia and neuronal ceroid lipofuscinosis
A.E. Arrant, V.C. Onyilo, D.E. Unger, and E.D. Roberson. (2018). J. Neurosci. 38:2341–2358.
Commentary in Nat. Rev. Neurology
Restoring neuronal progranulin reverses deficits in a frontotemporal dementia model
A.E. Arrant, A.J. Filiano, D.E. Unger, A.H. Young, and E.D. Roberson. (2017). Brain 140:1447–1465.
Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer’s disease
Hall, A.M., B.T. Throesch, S.C. Buckingham, S.J. Markwardt, Y. Peng, Q. Wang, D.A. Hoffman, and E.D. Roberson. (2015). Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer’s disease. J. Neurosci. 35:6221–6230
Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia
Warmus, B.A., D.R. Sekar, E. McCutchen, G.D. Schellenberg, R.C. Roberts, L.L. McMahon, and E.D. Roberson. (2014). J. Neurosci. 34:16482–16495.
Reducing endogenous tau ameliorates Aβ-induced deficits in an Alzheimer’s disease mouse model
Roberson, E.D., K. Scearce-Levie, J.J. Palop, F. Yan, I. Cheng, T. Wu, H. Gerstein, G.-Q. Yu, and L. Mucke. (2007). Science 316:750–754.
Commentary in N. Engl. J. Med.
Commentary in Nat. Rev. Neurosci.
Commentary on AlzForum